Unmatched Power & Versatility in Platelet Rich Plasma Formulation
PurePRP® SupraPhysiologic is a proprietary platelet concentrating system designed to deliver the highest concentrations of deliverable platelets at the point of care. Engineered for precision and versatility, this proprietary double-spin system allows physicians to customize PRP formulations and control the final treatment volume without compromising the biologic deliverables. It also provides the flexibility to produce neutrophil-rich or neutrophil-poor preparations. With an advanced, single-device design, PurePRP® SupraPhysiologic streamlines PRP preparation to under 10 minutes, ensuring consistent, predictable performance and optimized regenerative potential for superior patient outcomes.
Neutrophils play a crucial role in Platelet-Rich Plasma (PRP) preparations, influencing both the inflammatory response and tissue regeneration. In neutrophil-rich PRP (nr-PRP), these immune cells contribute to early-phase inflammation, pathogen defense, and the release of growth factors that modulate healing. Conversely, neutrophil-poor PRP (np-PRP) minimizes the inflammatory response, reducing the risk of excessive cytokine release, which may be beneficial in chronic conditions or delicate tissue applications. The choice between neutrophil-rich or neutrophil-poor PRP depends on the clinical application, balancing inflammation and regeneration to optimize patient outcomes.
PurePRP® SupraPhysiologic features advanced technology that precisely isolates neutrophils within the concentrating system, allowing for their selective extraction or retention based on clinical needs. This process ensures that platelet count and essential cellular mediators remain uncompromised, preserving the regenerative potential of the final PRP formulation.
Monocytes are unique immunoregulator cells in that they can sense, engulf, and kill bacteria, fungi, and parasites, helping to prevent the spread of infections. They differentiate into macrophages and dendritic cells, which are important for phagocytosis (engulfing and destroying pathogens) and antigen presentation (triggering adaptive immune responses). Monocytes help regulate immunity against foreign substances, contributing to the overall health of the immune system. can produce both pro and anti-inflammatory cytokines, helping to modulate the inflammatory response.
PurePRP® SupraPhysiologic is designed with advanced technology that selectively isolates high concentrations of monocytes in every PRP preparation, enhancing its immunomodulatory, antimicrobial, and regenerative properties. These monocytes play a critical role in orchestrating tissue repair, reducing excessive inflammation, and promoting an optimized healing environment for superior clinical outcomes.
The role of red blood cells (RBCs) in its formulation has been a subject of ongoing refinement. Excess RBC content in PRP formulations has been associated with pro-inflammatory effects, oxidative stress, and potential cytotoxicity, all of which can impede the regenerative process. The breakdown of RBCs leads to the release of hemoglobin and iron, which can contribute to oxidative damage and inflammation factors that may counteract the healing benefits of PRP. By reducing the RBC concentration, clinicians can mitigate these adverse effects, creating a more favorable microenvironment for tissue repair. However, the complete elimination of RBCs from PRP is not necessarily required. A minimal presence of RBCs at low levels does not exert a deleterious effect on tissue healing. In fact, trace amounts of RBCs may play a supportive role by maintaining physiological oxygen levels in the local tissue environment, which can be beneficial for cellular metabolism and angiogenesis.
PurePRP® SupraPhysiologic features advanced technology that efficiently removes over 99% of red blood cells while preserving clinically effective platelet concentrations in the final PRP sample. This optimized separation process enhances the regenerative potential of PRP by reducing unnecessary inflammatory byproducts while maintaining the biologic integrity of platelet-derived growth factors essential for healing.
PurePRP® SupraPhysiologic Concentrating Devices integrate a suite of proprietary technologies designed to optimize platelet isolation, cytokine enrichment, and overall PRP quality.
