Power of Multipotent Progenitor Stem Cells
PureBMC® SupraPhysiologic is a cutting-edge bone marrow concentrating system engineered to deliver superior BMC formulations enriched with the highest concentrations of hematopoietic stem cells, mesenchymal stem cells, deliverable platelets, and cytokine mediators, precisely at the point of care. Designed for unmatched versatility, this advanced system empowers physicians with precise control over final BMC volume and progenitor stem cell content while effectively minimizing free hemoglobin for optimal therapeutic potential. Featuring an innovative double-spin technology, PureBMC SupraPhysiologic streamlines preparation within a single device in under 10 minutes, ensuring predictability, consistency, and exceptional performance outcomes in regenerative medicine.
Hematopoietic stem cells (HSCs) play a pivotal role in bone marrow concentrate (BMC) preparations, offering unparalleled regenerative potential for tissue repair and immune modulation. These multipotent cells drive the formation of new blood and immune cells, enhancing the body’s natural healing processes and promoting recovery in orthopedic, vascular, and chronic wound applications. Enriched within a well-prepared BMC, HSCs work synergistically with mesenchymal stem cells, cytokines, and growth factors to accelerate tissue regeneration while reducing inflammation. By leveraging high concentrations of HSCs in a precisely formulated BMC, physicians can optimize patient outcomes, improving healing efficiency and clinical efficacy across various regenerative therapies.
PureBMC® SupraPhysiologic is designed with advanced technology that precisely isolates and captures hematopoietic stem cells, ensuring the highest possible concentrations for superior regenerative potential. Its innovative processing system optimizes cell recovery while minimizing free hemoglobin, delivering a potent and pure BMC formulation that enhances healing and clinical outcomes.
Mesenchymal stem cells (MSCs) in bone marrow concentrate play a critical role in regenerative healing due to their ability to differentiate into key tissue types such as bone, cartilage, and fat. Although MSCs make up only a small fraction of the total cell population in bone marrow aspirate—approximately 0.001% to 0.01%—their biological significance is profound, as they contribute to tissue repair, modulate inflammation, and support cellular regeneration. By concentrating bone marrow, the therapeutic potential of MSCs is enhanced, optimizing their availability and effectiveness in clinical applications. This enriched environment not only improves regenerative outcomes but also provides a more potent and versatile treatment option for musculoskeletal and orthopedic conditions.
PureBMC® SP AspiraDome™ technology revolutionizes bone marrow concentration by enabling the precise isolation and capture of mesenchymal stem cells (MSCs) with exceptional efficiency. This advanced system optimizes MSC retention while minimizing unwanted cellular contaminants, ensuring a highly potent and pure regenerative formulation for superior therapeutic outcomes.
The role of red blood cells (RBCs) in its formulation has been a subject of ongoing refinement. Excess RBC content in PRP formulations has been associated with pro-inflammatory effects, oxidative stress, and potential cytotoxicity, all of which can impede the regenerative process. The breakdown of RBCs leads to the release of hemoglobin and iron, which can contribute to oxidative damage and inflammation factors that may counteract the healing benefits of PRP. By reducing the RBC concentration, clinicians can mitigate these adverse effects, creating a more favorable microenvironment for tissue repair. However, the complete elimination of RBCs from PRP is not necessarily required. A minimal presence of RBCs at low levels does not exert a deleterious effect on tissue healing. In fact, trace amounts of RBCs may play a supportive role by maintaining physiological oxygen levels in the local tissue environment, which can be beneficial for cellular metabolism and angiogenesis.
PureBMC® SupraPhysiologic integrates advanced technology designed to enhance platelet collection in bone marrow concentrate, ensuring higher yields of deliverable platelets critical for tissue repair and regeneration. Its precision-engineered system optimizes platelet recovery while maintaining superior cell viability, delivering a potent and enriched BMC formulation that maximizes therapeutic potential at the point of care.
PureBMC® SupraPhysiologic Concentrating Devices integrate advanced proprietary technologies, such as side-port fenestrated needles for clean aspiration, precision microfiltration, and clean plasma suspension, to optimize the capture of high-quality bone marrow aspirate. This integrated approach enhances progenitor cell isolation and cytokine concentration while effectively minimizing free hemoglobin content, resulting in a purer, more potent bone marrow concentrate for regenerative applications.
