Minimizes Dilution, Maximizes Progenitor Cell Yield
Blunt Tip Side Fenestrated Aspiration
Razor Quad Tip Side Fenestrated Aspiration
The ASPIRE™ and ASPIRE AIM™ Bone Marrow Harvesting Systems represent advanced, clinically sophisticated technologies designed for the minimally invasive collection of high-quality bone marrow aspirate at the point of care. Each system incorporates specialized instrumentation engineered to optimize aspirate purity and cellular yield. Utilizing a unique fenestrated architecture and strategic aspirating pathways, these systems are capable of harvesting aspirate with an enriched concentration of progenitor stem cells. The devices are designed to penetrate the trabecular bone with precision and minimal disruption, preserving a quiescent tissue microenvironment during aspiration. This controlled approach significantly reduces tissue activation, free hemoglobin release, and clot formation. The result is an enhanced quality of bone marrow aspirate that is ideally suited for processing into a bone marrow concentrate with supraphysiologic levels of progenitor stem cells.
The ASPIRE™ and ASPIRE AIM™ Bone Marrow Harvesting Systems are specifically engineered to optimize the collection of bone marrow aspirate from the horizontal plane within the endosteal and sub-endosteal regions of parenchymal bone. These anatomical niches are well-documented as being highly enriched in hematopoietic progenitor cells and mesenchymal stem cells (MSCs), owing to their close association with the vascular sinusoidal network and osteoblastic microenvironment that support stem cell quiescence, proliferation, and differentiation.
By incorporating a 180-degree sequestering fenestration pattern along the lateral aspect of the aspiration cannula, the system enables comprehensive access to horizontally distributed marrow reservoirs. This design maximizes exposure to untouched, high-yield areas of marrow with a simple 90-degree rotation of the device, significantly expanding the surface area available for aspiration without requiring multiple cortical penetrations or repositioning.
The ASPIRE™ ergonomic and lightweight handle is expertly engineered to ensure even application of pressure during deployment through cortical bone and trabecular space. Its intuitive design enhances procedural efficiency, offering simplicity and comfort that fits naturally in the user’s hand. Strategically placed underlying ridges provide added grip stability, reducing hand fatigue during handling. A secure locking mechanism supports steady, sustained movement, giving users confidence and control throughout the procedure.
The ASPIRE™ bone marrow harvesting systems are equipped with a diamond-edge, razor-sharp quad bevel crown proximal tip that allows for minimally invasive coring with minimal effort. This precision tip ensures smooth and controlled penetration through cortical bone, reducing trauma to surrounding tissue. By preserving the porous architecture of the trabeculae, the system optimizes the collection of high-quality, viable progenitor stem cells. The result is a cleaner harvest with minimal red blood cell contamination, supporting more effective treatment outcomes.
The ASPIRE™ Harvesting Systems are engineered with fenestrated side ports and a closed distal tip to facilitate precise and controlled bone marrow aspiration. This configuration enables access to a wider cross-sectional area of the trabecular architecture, including niches known to be rich in hematopoietic progenitor cells. By eliminating distal suction and directing negative pressure laterally through the side ports, the system minimizes peripheral blood contamination while enhancing aspirate cellularity. Additionally, the closed-tip design allows for controlled depth and directional repositioning within the marrow cavity, improving yield consistency and procedural accuracy.
